- Title
- Sex ID Rapid Antigen Test: Refining research of imperilled reptile populations by eliminating hatchling sacrifice.
- Investigators
- Schwanz, Booth, Goldys, Deng, Li, Sifuentes-Romero, Carvajal, Wyneken
- Program
- Genetics & Genomics
- Class
- University
- Year(s)
-
2023 - 2023
- Funding agency
- Title
- The Epigenetics of Sex in the Dragon.
- Investigators
- Arthur Georges, Paul Waters, Clare Holleley, Aurora Ruiz-Herrera, Jennifer Graves, Ira Deveson and Sudha Rao
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2022 - 2026
- Summary
- Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $1,257,021.00
- Title
- Skinks with thermolabile sex as sensitive indicators of environmental change
- Investigators
- Dissanayake, D., Whiteley, S., Wagner, S., Nicotra, A., Kefford, B., Trewin, B., Holleley, C.E., Shine, R. and Georges, A.
- Program
- Genetics & Genomics
- Class
- University
- Year(s)
-
2021 - 2023
- Summary
- We live in increasingly volatile times, with human induced environmental change progressively moving from local to regional to global in scale. Climate change in particular is occurring at unprecedented rate, thought to be faster than species can respond through evolutionary processes, leading to local extinctions in areas where species are already pushing the boundaries of their physiological and ecological tolerances. These influences are particularly acute in the Australian high country where rising temperatures present increasing challenges to cold adapted species, some of which may face extirpation from their montane refugia.
The aim of this project is to examine responses of the three-lined skink to interannual climatic variation and long-term climatic trends, with special focus on the demographic implications of sex reversal on local population viability as a sensitive indicator of climatic change.
- Funding agency
- Grant amount
- $10,000.00
- Title
- Climate-ready science that engages citizens in conservation: Using two-ways conservation science of Australian sea turtles to cultivate a conservation-minded public.
- Investigators
- Schwanz, Rossini, Booth
- Program
- Genetics & Genomics
- Class
- University
- Year(s)
-
2021 - 2021
- Funding agency
- Title
- Australian Amphibian and Reptile Genomes (AusARG)
- Investigators
- Moritz, C. and Georges, A.
- Program
- Genetics & Genomics
- Class
- Government, National
- Year(s)
-
2020 - 2023
- Summary
- The Amphibian and Reptile Genome Initiative, led by representatives from the Australian museums, relevant universities and government agencies aims to:
(i) Build a foundation of genomic data to advance our understanding and conservation of Australia’s unique reptiles and amphibians;
(ii) Accelerate fundamental research of reptile and amphibian genomics in areas that Australia is uniquely placed to make its mark on the world stage;
(iii) Complement fundamental research with genomics to meet critical needs of conservation management and our unique reptile and amphibian biodiversity, as identified by society, government and industry;
(iv) Build a community across Australian museums, Universities and other research providers, and government agencies to sustain the initiative beyond the life of the Bioplatforms investment; and
(v) Increase awareness of the public and conservation managers of the diversity of Australian mammals and how genomics can aid in their conservation and management.
- Funding agency
- Grant amount
- $1,000,000.00
- Title
- Sex in Dragons -- genetics, epigenetics and environment.
- Investigators
- Georges, A., Deakin, J., Sarre, S.D., Ezaz, T., Waters, P., Schwanz, L., Graves, JAM, and Holleley, C.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2017 - 2020
- Summary
- Sex in many reptiles, like mammals, is determined by chromosomes. In others, sex is determined by the
temperature at which their eggs are incubated. This project aims to discover for the first time in a reptile, the
master sex determining gene, to discover how that gene is differentially regulated in males and females and by
temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex
determination. The model species, a dragon lizard, has chromosomal sex determination reversed by temperature,
providing a unique and tractable opportunity to examine the role of epigenetic gene regulation in sex
determination and the molecular basis for transitions between genetic and environmental sex determination.
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $1,006,500.00
- Title
- Was an ancient bird like sex chromosome system ancestral to reptiles and mammals?
- Investigators
- Ezaz, T., Georges, A., Jenny Graves, Sarre, S.D., Yoichi Matsuda
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2011 - 2014
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $345,000.00
- Title
- Gene environment interactions in reptile sex determination
- Investigators
- Georges, A. & Ezaz, T.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2011 - 2014
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $350,000.00
- Title
- Modelling responses to climate change in species with labile sex determination
- Investigators
- Georges, A., Gruber, B. & Ezaz, T.
- Program
- Conservation Ecology
- Class
- University
- Year(s)
-
2011 - 2013
- Funding agency
- University of Canberra
- Grant amount
- $350,000.00
- Title
- A Massively Parallel Genome Analysis Facility for the ACT Region
- Investigators
- Shannon, M.F. et al. (incl. Georges, A.)
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2009
- Funding agency
- Australian Research Council (LEIF Program)
- Grant amount
- $550,000.00
- Title
- Sex in Dragons: Evolution of sex determination in reptiles
- Investigators
- Sarre, S.D., Georges, A. Edwards, S.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2008 - 2010
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $383,000.00
- Title
- Sex markers in the Corroboree Frog
- Investigators
- Quinn A.E, Sarre, S.D., Georges, A
- Program
- Genetics & Genomics
- Class
- University
- Year(s)
-
2007 - 2008
- Funding agency
- University of Canberra
- Grant amount
- $25,000.00
- Title
- Sex in Dragons: The molecular basis of genetic and environmental sex determination.
- Investigators
- Graves, J., Sarre, S.D. & Georges, A.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2004 - 2007
- Summary
- We aim to discover the molecular basis of sex determination in closely related Australian reptiles (dragon lizards) with genetic sex determination (GSD) and temperature-dependent sex determination (TSD).
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $600,000.00
- Title
- Sex in Dragons: Probing the genotype-phenotype interaction in sex determination.
- Investigators
- Sarre, S.D. & Georges, A.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2003 - 2003
- Summary
- We aim to develop sex specific markers in a lizard with genotypic sex determination and apply them in a closely related species with temperature-dependent sex determination to identify concordant and discordant individuals.
- Funding agency
- Australian Research Council (Discovery Program)
- Grant amount
- $60,000.00
- Title
- Geographic variation in sex-determining attributes in a dragon with temperature-dependant sex determination
- Investigators
- Doody, J.S., Guarino, E. & Georges, A.
- Program
- Conservation Ecology
- Class
- University
- Year(s)
-
2003 - 2004
- Summary
- This project aims to determine the scope of wide ranging species with temperature dependent sex determination (TSD) to respond to climatic variation.
- Funding agency
- University of Canberra
- Grant amount
- $25,000.00
- Title
- Geographic variation in pivotal temperatures in the wide-ranging water dragon.
- Investigators
- Doody, J.S., Guarino, E., & Georges, A.
- Program
- Conservation Ecology
- Class
- University
- Year(s)
-
2002 - 2003
- Summary
- This project aims to investigate the scope for reptiles with temperature dependent sex determination to respond to variation in climate change.
- Funding agency
- University of Canberra
- Grant amount
- $25,000.00
- Title
- Evolution and mechanisms of sex determination in reptiles
- Investigators
- Sarre, S.D. & Georges, A.
- Program
- Genetics & Genomics
- Class
- Competitive, National
- Year(s)
-
2001 - 2002
- Summary
- This project is a pilot that aims to explore the mechanisms of sex determination using molecular approaches.
- Funding agency
- Australian Research Council (Small Grants Scheme)
- Grant amount
- $29,870.00
- Title
- Temperature-dependent sex determination in reptiles
- Investigators
- Georges, A.
- Program
- Conservation Ecology
- Class
- Competitive, National
- Year(s)
-
1996
- Funding agency
- Australian Research Council (Large Grants Scheme)
- Grant amount
- $226,000.00
- Title
- Temperature-dependent sex determination in Loggerhead turtles
- Investigators
- Georges, A.
- Program
- Conservation Ecology
- Class
- Competitive, National
- Year(s)
-
1990
- Funding agency
- Australian Research Council (Large Grants Scheme)
- Grant amount
- $75,000.00
- Title
- Temperature-dependent sex determination in <I>Chelodina longicollis</I>
- Investigators
- Georges, A.
- Program
- Conservation Ecology
- Class
- University
- Year(s)
-
1985
- Funding agency
- University of Canberra
- Grant amount
- $1,300.00
